A Cochrane review included 20 studies (of which 12 were placebo-controlled). All of the 10 trials reporting the duration of diarrhoea showed a significant reduction with antibiotics compared to placebo. Data from 6 trials demonstrated a greater number of participants being cured of diarrhoea by 72 hours (OR 5.9, 95% CI 4.06 to 8.57). Persons taking antibiotics experience more side effects than those taking placebo (OR 2.37, 95% CI 1.5 to 3.75).