Progestogen-releasing intrauterine system for uterine fibroids

Progestogen-releasing intrauterine system might possibly reduce menstrual blood loss in premenopausal women with uterine fibroids compared with combined oral contraceptives.

Comment: The level of evidence is downgraded by study quality (unclear allocation concealment and blinding, and incomplete outcome data).

Summary

A Cochrane review included 3 studies. However, data for progestogen-releasing intrauterine systems were available from only one study that compared 29 women with a levonorgestrel (LNG)-IUS versus 29 women with a combined oral contraceptive (COC) for treating uterine fibroids. There was a significant reduction of menstrual blood loss (MBL) in women receiving the LNG-IUS compared to the COC using the alkaline hematin test (mean difference (MD) 77.5%, 95% CI 71.3% to 83.67%; n=58) and a pictorial assessment chart (MD 34.5%, 95% CI 14.9% to 54.1%; n=58).

Date of latest search: 17 August 2012

Ədəbiyyat

1. Sangkomkamhang US, Lumbiganon P, Laopaiboon M et al. Progestogens or progestogen-releasing intrauterine systems for uterine fibroids. Cochrane Database Syst Rev 2013;(2):CD008994.