Single versus double intrauterine insemination (IUI) in stimulated cycles for subfertile couples

Double intrauterine insemination in stimulated cycles appears to result in higher pregnancy rate compared to single intrauterine insemination in the treatment of subfertile couples with husband semen.

A Cochrane review included 6 studies with a total of 1 785 women. The studies compared single versus double intrauterine insemination in stimulated cycles in subfertile couples. Pregnancy rate per couple showed a significant effect of using double insemination (Peto OR 1.8, 95% CI 1.4 to 2.4; 6 studies, n=1754). There were no data for the main outcome measure of live birth per couple or ongoing pregnancy rates, nor comparative data for adverse events.

Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment and inadequate intention-to-treat adherence).

Ədəbiyyat

1. Cantineau AE, Heineman MJ, Cohlen BJ. Single versus double intrauterine insemination (IUI) in stimulated cycles for subfertile couples. Cochrane Database Syst Rev 2003;(1):CD003854 [Review content assessed as up-to-date: 11 May 2008].