Cranberries for preventing urinary tract infections (UTIs)
Sübutlu məlumatların xülasələri
10.07.2017 • Sonuncu dəyişiklik 10.07.2017
Editors
Cranberry juice may decrease the number of symptomatic UTIs in women with recurrent UTIs compared to placebo.
The use of cranberry juice is suggested for the prevention of recurrent symptomatic urinary tract infections as the first choice over antibiotic prophylaxis.
The recommendation attaches a relatively high value to avoiding the development of antibiotic resistance in the community.
A review and meta-analysis included 13 trials involving a total of 1616 subjects, 10 of these trials (n=1494) were further analyzed in quantitative synthesis. Cranberry juice was used in 9 trials and capsules or tablets in 4 trials. Daily cranberry dose ranged from 0.4 to 194.4g and the duration of use was mostly 6 months. Cranberry was effective in prevention of UTIs; the random-effects pooled risk ratio (RR) for cranberry users vs nonusers was 0.62 (95% CI 0.49 to 0.80; I²=43%; 9 trials, n=1175). On subgroup analysis, cranberry-containing products seemed to be more effective in several subgroups, including women with recurrent UTIs (RR 0.53, 95% CI 0.33 to 0.83; 2 trials, n=250), female populations (RR 0.49, 95% CI 0.34 to 0.73; 4 trials, n=492), children (RR 0.33, 95% CI 0.16 to 0.69; 2 trials, n=84), cranberry juice drinkers (RR 0.47, 95% CI 0.30 to 0.72; 5 trials, n=748), and subjects using cranberry-containing products more than twice daily (RR 0.58, 95% CI 0.40 to 0.84; 4 trials, n=668).
included 24 studies with a total of 4473 subjects evaluating the effectiveness of cranberry juice (13 trials, n=2380) or tablets /capsules (9 trials, n=1032). Cranberry products did not significantly reduced the incidence of symptomatic UTIs overall (RR 0.86, 95% CI 0.71 to 1.04; 13 trials, n=2462) or for any the subgroups: women with recurrent UTIs (RR 0.74, 95% CI 0.42 to 1.31; 4 trials, n=594); older people (RR 0.75, 95% CI 0.39 to 1.44; 2 trials, n=413); pregnant women (RR 1.04, 95% CI 0.97 to 1.17; 2 trials, n=674); children with recurrent UTI; cancer patients; or people with neuropathic bladder or spinal injury. The effectiveness of cranberry was not significantly different to antibiotics for women (RR 1.31, 95% CI 0.85 to 2.02; 2 trials, n=344) and children (RR 0.69 95% CI 0.32 to 1.51; 1 trial, n=192). There was no significant difference between gastrointestinal adverse effects from cranberry product compared to those of placebo/no treatment."?>
Comment: The quality of evidence is downgraded by limitations in study quality (unclear allocation concealment in most of the studies and variable loss to follow up).
Ədəbiyyat
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- Wang CH, Fang CC, Chen NC et al. Cranberry-containing products for prevention of urinary tract infections in susceptible populations: a systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 2012;172(13):988-96.