A systematic review including 5 RCTs and 73 other studies with a total of 1834 subjects was abstracted in DARE. Single-agent chemotherapy resulted in 62% complete or partial response. Combination chemotherapy resulted in 81% complete or partial response. Several other treatments resulted in greater than 50% response.
Comment: The level of evidence is downgraded by inconsistency (differences in interventions and outcomes). The data included in the review are principally case series.