Preoperative radiotherapy for rectal cancer
Sübutlu məlumatların xülasələri
19.04.2018 • Sonuncu dəyişiklik 19.04.2018
Editors
Pre-operative radiotherapy followed by surgery is more effective than surgery alone for preventing local recurrence of rectal cancer, and may also improve survival.
A systematic review including 15 studies with a total of 7,985 subjects was abstracted in DARE. Overall mortality was lower in the treatment group (pre-operative radiotherapy) compared with the control groups (14 studies; RR 0.94, 95% CI: 0.89, 0.99, P=0.021). The pooled results for local failure rate (13 studies; RR 0.71, 95% CI: 0.57 to 0.89, P=0.0025) and incidence of stage III tumours (15 studies; RR 0.84, 95% CI: 0.74 to 0.95, P=0.006) significantly favoured the treatment group.
Ədəbiyyat
- Figueredo A, Zuraw L, Wong RK, Agboola O, Rumble RB, Tandan V, Cancer Care Ontario's Program in Evidence-based Care's Gastrointestinal Cancer Disease Site Group. The use of preoperative radiotherapy in the management of patients with clinically resectable rectal cancer: a practice guideline. BMC Med 2003 Nov 24;1:1.