A topic in Clinical Evidence summarizes the results of trials on nitromidazole antibiotics for amoebic dysentery. One RCT (n=55) found that ornidazole reduced failure rate of parasitic clearance (AR 7/35 (20.0%) with ornidazole vs 20/20 (100%) with placebo. There were six RCTs comparing tinidazole and metronidazole. Four RCTs found improved parasite clearance at 30 days with tinidazole, two found no difference. Clinical Evidence category: Likely to be beneficial.
Comment: The quality of evidence is downgraded by imprecise results (limited study size for each comparison).