Oral antihistamine-decongestant-analgesic combinations for the common cold
Sübutlu məlumatların xülasələri
17.11.2011 • Sonuncu dəyişiklik 17.11.2011
Editors
Antihistamine-analgesic-decongestant combinations may have some general benefit for adults and older children with common cold.
A Cochrane review included 27 studies with a total of 5117 participants with common cold. Studied treatment combinations were antihistamine-decongestant (n=14); antihistamine-analgesic (n=2); analgesic-decongestant (n=6) and antihistamine-analgesic-decongestant (n=5). In 21 trials the control was placebo and in 6 trials an active comparator.
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Antihistamine-decongestant (12 trials, 6 could be pooled, n = 621): OR of treatment failure was 0.27 (95% CI 0.15-0.50; NNT 4). On the final evaluation day 41% of participants in the placebo group had a favourable response compared to 66% on active treatment.
The combination had more adverse effects than the control intervention but the difference was not significant.
- Antihistamine-analgesic (3 trials, data from one study was presented, n = 582). The OR of treatment failure was 0.33 (95% CI 0.23 - 0.46; NNT 6.67). A total of 12% in the combination group suffered from adverse effects vs. 10% in the control group (OR 1.27, 95% CI 0.50 to 3.23).
- Analgesic-decongestant (6 trials): One trial reported on global effectiveness. In the active treatment group 73% benefited vs. 52% in the control group (paracetamol) (OR 0.28, 95% CI 0.15 - 0.52).
The combination had significantly more adverse effects than control (OR 1.71, 95% CI 1.23 to 2.37); NNT for an additional harmful outcome was 14.
- Antihistamine-analgesic-decongestant (5 trials, 2 could be pooled): OR of treatment failure was 0.47 (95% CI 0.33 to 0.67; NNT 5.6).
Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment) and inconsistency (heterogeneity in design, participants, interventions and outcomes).
Ədəbiyyat
- De Sutter AI, van Driel ML, Kumar AA et al. Oral antihistamine-decongestant-analgesic combinations for the common cold. Cochrane Database Syst Rev 2012;2:CD004976.