Comment: The quality of evidence is downgraded by study limitations (selective outcome reporting) and by imprecise results (few patients and outcome events, wide confidence intervals).
A Cochrane review included 5 studies with a total of 960 subjects. There were no significant differences in the incidence of mastitis between use of antibiotics and no antibiotics (RR 0.43; 95% CI 0.11 to 1.61; 3 trials, n=471) or between two different doses (RR 0.38; 95% CI 0.02 to 9.18; 1 trial, n=99). No significant differences were found for mastitis in three trials of specialist breastfeeding education compared with usual care (1 trial); anti-secretory factor cereal (1 trial); and mupirocin, fusidic acid ointment or breastfeeding advice (1 trial).
Date of latest search: 8 August 2012