Non-surgical interventions for late radiation proctitis
Sübutlu məlumatların xülasələri
13.01.2017 • Sonuncu dəyişiklik 13.01.2017
Editors
Rectal sucralfate and adding metronidazole to an anti-inflammatory regimen might possibly provide some benefit, although there is no evidence from controlled trials.
A Cochrane review included 6 studies with a total of 184 subjects. Rectal sucralfate showed greater clinical improvement for proctitis than anti-inflammatories (OR 14,0, 95% CI 1.46 to 134 in one study), though no significant difference was seen in endoscopic improvement (OR 2.74, 95% CI 0.64 to 11.76). The addition of metronidazole to the anti-inflammatory regimen also appeared to improve the response rate, as measured by the reduction in rectal bleeding, diarrhoea, erythema and ulceration (1 study).
Ədəbiyyat
- Denton A, Forbes A, Andreyev J, Maher EJ. Non surgical interventions for late radiation proctitis in patients who have received radical radiotherapy to the pelvis. Cochrane Database Syst Rev 2002;(1):CD003455.