Pharmacological interventions for spasticity following spinal cord injury
Sübutlu məlumatların xülasələri
29.08.2018 • Sonuncu dəyişiklik 29.08.2018
Editors
Intrathecal baclofen and oral tizanidine might possibly have some beneficial effects in patients with spasticity following spinal cord injury, but the data are insufficient.
A Cochrane review included 9 studies. Two studies (n=14) showed a significant effect of intrathecal baclofen in reducing spasticity. One study comparing tizanidine to placebo showed a significant effect in improving Ashworth Score but not in ADL performances.
Comment: The quality of evidence is downgraded by inconsistency (heterogeneity in outcomes), by indirectness (differences in studied interventions), and by imprecise results (limited study size for each comparison).
Ədəbiyyat
- Taricco M, Adone R, Pagliacci C, Telaro E. Pharmacological interventions for spasticity following spinal cord injury. Cochrane Database Syst Rev 2000;(2):CD001131.