Combination of nicotine replacement therapy and bupropion for smoking cessation

Bupropion appears not to enhance the effect of nicotine replacement therapy (NRT) compared with NRT alone.

Summary

A Cochrane review included 6 studies with a total of 2695 subjects. Combining nicotine replacement therapy (NRT) (patch/gum/lozenge) with bupropion was more effective than bupropion alone (RR 1.24, 95% CI 1.06 to 1.45; 4 trials, n=1991). Combining nicotine patch with bupropion was more effective than placebo (RR 3.99, 95% CI 2.03 to 7.85; 1 trial, n=405). However combining nicotine lozenge with bupropion showed no significant effect (RR 1.54, 95% CI 0.81 to 2.90; 1 trial, n=405).

Another Cochrane review included a network meta-analysis of 12 treatment-specific reviews (267 studies) involving 101804 participants. Bupropion was less effective than combination NRT (OR 0.68, CredI 0.5 to 0.91; indirect comparison). Bupropion was not shown to enhance the effect of NRT compared with NRT alone in 6 trials.

Ədəbiyyat

1. Stead LF, Perera R, Bullen C et al. Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev 2012;(11):CD000146.
2. Cahill K, Stevens S, Perera R et al. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev 2013;(5):CD009329.