A systematic review including 8 studies with a total of 1208 subjects was abstracted in DARE. Of these, two (70 participants) were randomised controlled trials, one (294 participants) was a retrospective study, and the designs of the remaining five studies (844 participants) were unclear. Significantly fewer participants experienced coronary artery aneurysms with corticosteroids as compared with control (OR 0.546 95% CI: 0.371, 0.803, P=0.002; 8 studies). Participants receiving corticosteroids plus aspirin and intravenous immunoglobulin (IVIG) had fewer aneurysms than those receiving aspirin plus IVIG alone (OR 0.352, 95% CI: 0.136, 0.909, P=0.031; 3 studies).
Comment: The quality of evidence is downgraded by imprecise results (few patients and wide confidence intervals in RCTs) and limitations in review methdology (the studies that were excluded from the analysis were done so on the basis of heterogeneity rather than quality).