A Cochrane review included one study with a total of 25 subjects with amyotrophic lateral sclerosis. The included study was a trial of moderate intensity, endurance type exercise versus 'usual activities' in 25 patients . At three months patients performing the 15 minute twice daily exercises had significantly less spasticity overall (mean reduction of –0.43, 95% CI –1.03 to +0.17 in the treatment group versus an increase of +0.25, 95% CI –0.46 to +0.96 in control) but the mean change between groups was not significant (–0.68, 95% CI –1.62 to +0.26), as measured by the Ashworth scale. No analysis was possible at 9 and 12 months.
Comment: The quality of evidence is downgraded by study quality (inadequate allocation concealment and blinding, high drop-out rate, short follow-up time) and imprecise results (few patients and wide confidence intervals).