The urine trypsinogen-2 dipstick test was compared in 500 consequtive emergency department patients with acute abdominal pain to quantitative urine trypsinogen-2 measurement, serum and urine amylase and urine amylase dipstick test . Trypsinogen-2 dipstick test was positive in 50/53 patients with acute pancreatitis diagnosed according to standardized criteria (sensitivity 93%) and in 21/447 patients without acute pancreatitis (specificity 95%), with a cutoff value of 50 µg/l per liter for the upper reference limit). The sensitivity and specificity were superior to serum amylase (85% and 91%, with a cutoff value of 300 U per liter for the upper reference limit) or urine amylase dipstick test (83% and 88%, with a cutoff value of 2000 U per liter for the upper reference limit).
Comment: The quality of evidence is downgraded by imprecise results (limited study size).