Drug treatment for myotonia
Sübutlu məlumatların xülasələri
03.07.2018 • Sonuncu dəyişiklik 03.07.2018
Editors
Evidence is insufficient to determine whether drug treatment is safe and effective in the treatment of myotonia. Clomipramine and imipramine might possibly have a short-term and taurine a long-term beneficial effect on myotonia but larger, well-designed trials are needed.
A Cochrane review included 10 studies with a total of 143 participants (113 with myotonic dystrophy type 1 and 30 with myotonia congenita). Twelve different drugs were used in the studies which were of poor quality. Two small crossover studies without a washout period demonstrated a significant effect of imipramine and taurine in myotonic dystrophy. One small crossover study with a washout period demonstrated a significant effect of clomipramine in myotonic dystrophy. Meta-analysis was not possible.
Ədəbiyyat
- Trip J, Drost G, van Engelen BG, Faber CG. Drug treatment for myotonia. Cochrane Database Syst Rev 2006;(1):CD004762 [Review content assessed as up-to-date: 29 July 2009].