Treatments for oral lichen planus

Cyclosporin may reduce pain and clinical signs of oral lichen planus. There is no evidence that steroids are more effective than placebo or that one steroid is more effective than another in reducing pain in symptomatic OLP.

A Cochrane review on therapies for symptomatic oral lichen planus (OLP) included 28 studies. Primary outcome was reduction of pain. Pimecrolimus was no better than placebo (3 trials). Aloe vera may be associated with a reduction in pain compared to placebo (2 low quality trials). Cyclosporin may reduce pain and clinical signs of OLP (2 low quality trials). Although topical steroids are considered first line treatment for symptomatic OLP, there were no RCTs that compared steroids with placebo. There was no difference between treatment with steroids compared to calcineurin inhibitors (5 trials). Any specific steroid therapy was not shown to be more or less effective at reducing pain compared to another type or dose of steroid (6 trials).

Ədəbiyyat

1. Thongprasom K, Carrozzo M, Furness S, Lodi G. Interventions for treating oral lichen planus. Cochrane Database Syst Rev 2011;(7):CD001168.