In a randomised study 160 patients (mean age 55.1 years) with type 2 diabetes and microalbuminuria received either an intensified multiple risk factor intervention (dietary fat composition, exercise recommendation, smoking-cessation courses, ACE inhibitors irrespective of blood pressure level, aspirin, antihypertensive medication, hypoglycaemic agents, and statins or fibrates (for those with hypercholesterolaemia or hypertriglyceridaemia) or conventional care . Patients receiving intensive therapy had a significantly lower risk of cardiovascular disease (hazard ratio 0.47, 95% CI 0.24 to 0.73), nephropathy (HR 0.39, 95% CI 0.17 to 0.87), retinopathy (HR 0.42, 95% CI 0.21 to 0.86) and autonomic neuropathy (HR 0.37, 95% CI 0.18 to 0.79).
Comment: The quality of evidence is downgraded by imprecise results (few patients and wide confidence intervals).