Preoperative autologous donation of blood

Pre-operative donation of autologous blood may reduce exposure to allogeneic blood transfusion but appears to increase exposure to any transfusion.

A Cochrane review included 14 studies with a total of 1 707 subjects. Overall pre-operative autologous blood donation (PAD) reduced the risk of receiving an allogeneic blood transfusion by a relative 68% (RR 0.32, 95% CI 0.22 to 0.47; statistically significant heterogeneity I² = 70%). The absolute reduction in risk of allogeneic transfusion was 44% (RD -0.44, 95% CI -0.68 to -0.21). In contrast, the risk of receiving any blood transfusion (allogeneic and/or autologous) increased by PAD (RR 1.24, 95% CI 1.02 to 1.51; statistically significant heterogeneity I² = 89%).

Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment and lack of blinding) and by potential reporting bias.

Ədəbiyyat

1. Henry DA, Carless PA, Moxey AJ, O'Connell D, Forgie MA, Wells PS, Fergusson D. Pre-operative autologous donation for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2002;(2):CD003602 [Review content assessed as up-to-date: 31 July 2009].