A systematic review including 10 studies with a total of 562 subjects was abstracted in DARE. Results from all four studies comparing medroxyprogesterone acetate with tamoxifen showed a statistically significant difference in global response rates in favour of medroxyprogesterone acetate. No statistically significant differences between groups were found in three studies comparing megestrol acetate with tamoxifen. One study demonstrated a statistically significant effect of medroxyprogesterone acetate as compared to megestrol acetate.