A topic in Clinical Evidence summarizes the results of three RCTs (total n=223). All RCTs found that topical interferon increased complete wart clearance at 4 weeks compared with placebo (6% vs 3%, 73% vs 10%, and 90% vs 20%). One of the RCTs found that interferon was more effective than podophyllotoxin (90% vs 60%).
Comment: The quality of evidence was downgraded by sparse data (limited study size for each comparison).