A Cochrane review included 3 studies with a total of 215 subjects. Comparison interventions included no treatment, Poly vitamins, and leuprolide acetate depot plus raloxifene versus leuprolide plus placebo tablet. There was a tendency towards fibroid reduction with selective estrogen receptor modulators (SERMs), although this was not significant in all studies. All three studies mentioned adverse reactions but no detailed data were acquired in the included studies.
Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment and by imprecise results) few studied patients.