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Glucocorticosteroids for primary biliary cirrhosis

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Glucocorticosteroids for primary biliary cirrhosis

Sübutlu məlumatların xülasələri
02.03.2015 • Sonuncu dəyişiklik 02.03.2015
Editors

There is insufficient evidence on the effects of glucocorticosteroids for primary biliary cirrhosis.

A Cochrane review included 2 underpowered studies with a total of 76 subjects. The studies differed markedly in their inclusion criteria and treatment protocols. Both stated that they used placebo. However, allocation concealment was unclear. Only one trial reported any patient deaths. No significant improvement in mortality was identified (odds ratio (OR) 0.42, 95% confidence interval (CI) 0.10 to 1.76). Improvements in serum markers of liver inflammation and liver histology were identified. Potentially prognostically linked markers such as bilirubin and albumin were incompletely reported. Bone mineral density (weighted mean difference -2.84%, 95% CI -4.16 to -1.53) and the number of patients with any adverse event (OR 8.99, 95% CI 2.15 to 37.58) were significantly increased in the glucocorticosteroid group.

Ədəbiyyat

  1. Prince M, Christensen E, Gluud C. Glucocorticosteroids for primary biliary cirrhosis. Cochrane Database Syst Rev 2005 Apr 18;(2):CD003778.