Comparative efficacy of different proton-pump inhibitors in triple therapy for Helicobacter pylori eradication

There appears to be no difference in the efficacy of different PPIs when used in standard triple therapy for H. pylori eradication.

A systematic review including 14 studies with a total of 3,199 subjects was abstracted in DARE. There was no statistically significant difference in eradication rate between omeprazole and lansoprazole (6 studies; OR 0.91, 95% CI: 0.69 to 1.21); omeprazole and rabeprazole (4 studies; OR 0.81, 95% CI: 0.58 to 1.15); omeprazole and esomeprazole (2 studies; OR 0.89, 95% CI: 0.58 to 1.35); lansoprazole and rabeprazole (3 studies; OR 0.77, 95% CI: 0.48 to 1.22).

Comment: The quality of evidence is downgraded by sparse data (the difference between rabeprazole and comparator drugs might be clinically significant if the results were statistically significant).

Ədəbiyyat

1. Vergara M, Vallve M, Gisbert JP, Calvet X. Meta-analysis: comparative efficacy of different proton-pump inhibitors in triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther 2003 Sep 15;18(6):647-54.