Inhaled corticosteroids for prevention of exercise induced bronchoconstriction

Inhaled corticosteroids given for at least 4 weeks may attenuate exercise-induced bronchoconstriction in both adults and children.

A Cochrane review included 8 studies (2 involving adults, 6 children) with a total of 162 participants. Combining results from the 3 parallel studies with at least 4 weeks duration of inhaled corticosteroids, the use of inhaled corticosteroids significantly attenuated the percent fall index in forced expiratory volume in 1 second (WMD 11.74%; 95% CI 10.06% to 13.42%; statistical heterogeneity I² 81%). The result from one crossover study with duration of inhaled corticosteroids of 4 weeks revealed significant attenuation of percent fall in forced expiratory volume in 1 second (WMD 6.90%; 95% CI 1.40% to 12.40%) and the percent fall in peak expiratory flow (WMD 11.50%; 95% CI 6.31% to 16.69%). The small amount of data from placebo-controlled trials using a single treatment do not currently allow conclusions to be drawn.

Comment: The quality of evidence is downgraded by study quality (unclear allocation concealment) and by imprecice results (few patients).

Ədəbiyyat

1. Koh MS, Tee A, Lasserson TJ, Irving LB. Inhaled corticosteroids compared to placebo for prevention of exercise induced bronchoconstriction. Cochrane Database Syst Rev 2007;(3):CD002739 [Review content assessed as up-to-date: 28 October 2008].