A topic in Clinical Evidence summarizes the results of three small RCTs. One RCT (n=83) found that a nocturnal hand brace improved symptoms at 2 and 4 weeks compared to no treatment (Boston Carpal Tunnel Syndrome Questionnaire, 4 weeks: -1.07, 95% CI -2.01 to -0.13). One RCT (90 wrists) found no difference between neutral and 20° extension. One RCT (n=24) found no differenbe between full-time and night time only splint. Comment: Quality of evidence is downgraded by sparse data.