A topic in Clinical Evidence summarizes the results of one systematic review (search date 2000, 5 RCTs, 1077 people) and two subsequent RCTs. Naratriptan increased headache relief compared with placebo (ARI 22.2%, 95% CI 16.9% to 27.5%). The first subsequent RCT compared naratriptan 2.5 mg, sumatriptan 100 mg and placebo. Both increased headache relief at 4 hours (AR 63% with naratriptan vs 80% with sumatriptan vs 31% with placebo). One systematic review (search date 2000, 2 RCTs, 480 people) found that sumatriptan 100 mg increased headache relief compared with naratriptan 2.5 mg (ARI 8%, 95% CI 0% to 16%). A subsequent RCT did not find any difference in headache recurrence between sumatriptan 100 mg and naratriptan 2.5 mg.