A Cochrane review included 1 study with a total of 38 women (41 pregnancies). Only 26 women (28 pregnancies) were analysed. Betamethasone (1.5 mg/day) compared with no medication found no statistically significant difference in neonatal thrombocytopenia (RR) 1.12, 95% CI 0.62 to 2.05) and neonatal bleeding (RR 1.00, 95% CI 0.24 to 4.13). An intention-to-treat analysis which showed similar findings: RR 1.18, 95% CI 0.57 to 2.45 and RR 1.05, 95% CI 0.24 to 4.61, respectively. Maternal death, perinatal mortality, postpartum haemorrhage and neonatal intracranial haemorrhage were not studied by this RCT.
Comment: The quality of evidence is downgraded by study quality (inadequate or unclear allocation concealment), high attrition rate and imprecise results (few patients and wide confidence intervals). .