A Cochrane review (abstract , review ) included 3 studies with a total of 78 patients. Administration of 15 minutes of AL-TENS a week, for 3 weeks, resulted in a significant decrease in rest pain (67% relative benefit, 45 points absolute benefit on 100 mm VAS scale) but not in grip pain compared to placebo. No significant difference was found between one 20-minute treatment duration of C-TENS versus AL-TENS , or C-TENS versus placebo on decrease in mean scores for rest pain or grip pain, or on the number of tender joints, but there was a clinically important benefit of C-TENS over AL-TENS on patient assessment of change in disease (risk difference 21%, NNT 5).
Comment: The quality of evidence is downgraded by study quality (inadequate or unclear allocation concealment) and by imprecise results (few patients and wide confidence intervals).