A Cochrane review included 6 studies with a total of 370 subjects. Different antifungal drugs were compared: 1% topical itraconazole versus 1% topical itraconazole and oral itraconazole, different concentrations of silver sulphadiazine versus 1% miconazole, 1% silver sulphadiazine ointment versus 1% miconazole ointment, 2% econazole versus 5% natamycin, different concentrations of topical chlorhexidine gluconate versus 5% natamycin, and 0.2% chlorhexidine gluconate versus 2.5% natamycin. No single reference drug was used. All trials considered clinical cure as primary outcome. Comparing treatment effects of all the drug preparations studied, silver sulphadiazine ointment had the lowest proportion of participants with treatment failure followed by itraconazole, miconazole, chlorhexidine, econazole, and the drug with the most treatment failure was natamycin. These differences were not, however, statistically significant which might in part be due to low sample sizes.
Comment: The quality of evidence is downgraded by study quality (inadequate or unclear allocation concealment), by inconsistency (heterogeneity in interventions) and by imprecise results (limited study size for each comparison).