Risk of pulmonary embolism associated with factor V (FVa) Leiden
Sübutlu məlumatların xülasələri
10.05.2016 • Sonuncu dəyişiklik 10.05.2016
Editors
The increase in the risk of isolated pulmonary embolism associated with factor V (FVa) Leiden may be smaller than that of deep vein thrombosis.
According to 5 studies summarized in an editorial of the Lancet, the odds ratio for developing isolated pulmonary embolism in carriers of FVa mutation is consistently smaller (2.5, 95% CI 1.8 to 3.5) than the odds ratio for developing isolated deep vein thrombosis (OR 6.0, 95% CI 4.6 to 7.8) or deep vein thrombosis and pulmonary embolism (OR 5.2, 95% CI 3.6 to 7.5). According to one study, thrombosis occurred strikingly less often in the iliofemoral veins among factor V Leiden carriers (2.8% vs 23.2%, p<0.01) . In addition, thrombi in these patients were significantly smaller than in non-carriers.
Ədəbiyyat
- Bounameaux H. Factor V Leiden paradox: risk of deep-vein thrombosis but not of pulmonary embolism. Lancet 2000 Jul 15;356(9225):182-3.
- Björgell O, Nilsson PE, Nilsson JA, Svensson PJ. Location and extent of deep vein thrombosis in patients with and without FV:R 506Q mutation. Thromb Haemost 2000 May;83(5):648-51.