A population based nested case-control study comprised a total of 19 637 patients who had been diagnosed as having and treated for schizophrenia. A total of 451 incident cases of diabetes were matched with 2696 controls.
Patients taking olanzapine had a significantly increased risk of developing diabetes than non-users of antipsychotics (odds ratio 5.8, 95% confidence interval 2.0 to 16.7) and those taking conventional antipsychotics (4.2, 1.5 to 12.2).
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