Venlafaxine for depression

Venlafaxine is at least as effective as tricyclic antidepressants and appears to be more effective than selective serotonin reuptake inhibitors for mild to moderate depression.

A topic in Clinical Evidence summarizes the results of systematic reviews comparing venlafaxine with other kinds of antidepressants. One systematic review (search date 2000) including 8 RCTs with a total of 1356 people found no significant difference between venlafaxine and tricyclic antidepressants in the proportion of people that responded over 1 month to 1 year (defined as at least 50% response on a continuous rating scale): OR 1.29, 95% CI 0.89 to 1.85. One systematic review (search date 2000) including 20 RCTs with a total of 3844 people found that venlafaxine increased the proportion of people who responded over 1 month to 1 year compared to selective serotonin reuptake inhibitors: RR 1.26, 95% CI 1.02 to 1.58).

Ədəbiyyat

1. Geddes J, Butler R, Hatcher S, Cipriani A. What are the effects of treatments in mild to moderate or severe depression? Clinical Evidence 2005;13:1244-1263.