A Cochrane review included 9 studies with a total of 2 210 subjects. Smoking cessation rates in later pregnancy were higher with NRT as compared to control (RR 1.41, 95% CI 1.03 to 1.93; 8 studies, n=2199). Subgroup analysis of placebo-RCTs provided a lower RR in favour of NRT (RR 1.28, 95% CI 0.99 to 1.66; 5 studies, n=1926. There were no statistically significant differences in rates of miscarriage, stillbirth, premature birth, birthweight, low birthweight, admissions to neonatal intensive care or neonatal death between NRT or control groups. There were no trials of varenicline or bupropion.
Date of latest search: 26 March 2018