Rutosides for treatment of post-thrombotic syndrome

Rutosides may not be effective for treatment of post-thrombotic syndrome.

The quality of evidence is downgraded by study limitations (lack of blinding) and by imprecise results (few patients and outcome events).

Summary

A Cochrane review included 3 studies with a total of 233 subjects. One study compared rutoside with placebo, one study compared rutosides with elastic compression stockings (ECS) and rutosides plus ECS versus ECS alone, and one study compared rutosides with an alternative venoactive remedy (hidrosmina). Rutosides appeared not to be better than placebo/no treatment or ECS (Table ). Occurrence of leg ulceration was not reported in any of the included studies. One study reported on adverse effects showing higher odds of mild adverse effects in the rutoside treated group compared to placebo but this was not statistically significant.

Clinical comments

Date of latest search:

Ədəbiyyat

1. Morling JR, Yeoh SE, Kolbach DN. Rutosides for treatment of post-thrombotic syndrome. Cochrane Database Syst Rev 2013;(4):CD005625.