A Cochrane review included 11 trials with a total of 8 184 participants (6 586 adults and 1 598 children). Different versions of three types of TBE vaccines were tested (IPVE, FSME-IMMUN, and Encepur). No trials reported on cases of clinical TBE, but all reported on antibody titre (seroconversion). All the vaccines gave seroconversion rates of over 87%. There were frequent reports of systemic and local adverse effects, none of which were severe.
Comment: The quality of evidence is downgraded by limitations in study quality (inadequate or unclear allocation concealment).