Dressings and topical agents for arterial leg ulcers

There is insufficient evidence to determine whether the choice of topical agent or dressing affects the healing of arterial leg ulcers.

The quality of evidence is downgraded by study limitations (unclear allocation concealment and blinding), by indirectness (differences between the outcomes of interest and those reported), and by imprecise results (few patients and outcome events).

Summary

A Cochrane review (abstract , review ) included 1 study with a total of 40 patients with arterial leg ulcers. This trial compared ketanserin ointment in polyethylene glycol (PEG) with vehicle (PEG) alone, changed twice a day. The study demonstrated increased wound healing in the ketanserin group compared with the control group, but the trial was too small and had too short a follow-up period (8 weeks) to be able to determine whether there was any difference in healing rates.

Note

Ketanserin is not licensed in all countries for use in humans.

Ədəbiyyat

1. Forster R, Pagnamenta F. Dressings and topical agents for arterial leg ulcers. Cochrane Database Syst Rev 2015;(6):CD001836.