Cyproterone acetate for hirsutism
Sübutlu məlumatların xülasələri
13.07.2017 • Sonuncu dəyişiklik 13.07.2017
Editors
Cyproterone acetate combined with etinyl estradiol may be effective for hirsutism compared with placebo or desogestrel.
A Cochrane review (, review ) included 1 study on cyproterone acetate combined with ethinyl estradiol compared to placebo, with a total of 20 patients. There were no clinical trials comparing cyproterone acetate alone with placebo. In this study there was a significant subjective reduction in hair growth with cyproterone acetate therapy, although the confidence limits were large (OR 45.0, 95% CI 2.01 to 1006.80). In studies where cyproterone acetate was compared to other drug modalities (ketoconazole, spironolactone, flutamide, finasteride,
GnRH analogues) no difference in clinical outcome was noted.
Another Cochrane review ( ) assessed different medical interventions. Cyproterone acetate combined with ethinyl estradiol relieved hirsutism more than desogestrel combined with ethinyl estradiol: improvement in hirsutism with Ferriman- Gallwey score (scale 0 to 36) was - 1.69 to -9.51 with desogestrel and -1.84 (95% CI -3.85 to 0.18) lower with cyproterone acetate (non-significant difference) in 3 trials, n=164.
Comment: The quality of evidence is downgraded by study quality (inadequate or unclear blinding and allocation concealment) and by imprecise results (few patients and wide confidence intervals).
Ədəbiyyat
- Van der Spuy ZM, le Roux PA. Cyproterone acetate for hirsutism. Cochrane Database Syst Rev 2003;(4):CD001125.
- van Zuuren EJ, Fedorowicz Z, Carter B et al. Interventions for hirsutism (excluding laser and photoepilation therapy alone). Cochrane Database Syst Rev 2015;(4):CD010334.