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Taxanes for adjuvant treatment of early breast cancer

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Taxanes for adjuvant treatment of early breast cancer

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14.07.2017 • Sonuncu dəyişiklik 14.07.2017
Editors

Taxanes are effective as adjuvant chemotherapy regimens for improving overall and disease-free survival for women with operable early breast cancer compared to non-taxane regimens.

A Cochrane review included 12 studies involving a total of 21 191 women. The weighted average median follow up was 60.4 months. The HR for overall survival was 0.81 (95% CI 0.75 to 0.88, P < 0.00001, 2 483 deaths amongst 18 304 women) favouring taxane (paclitaxel or docetaxel) containing regimens. The HR for disease-free survival was 0.81 (95% CI 0.77 to 0.86, P < 0.00001, 4 800 events in 19 943 women) favouring taxane containing regimens. There was no statistical heterogeneity.

Ədəbiyyat

  1. Ferguson T, Wilcken N, Vagg R, Ghersi D, Nowak AK. Taxanes for adjuvant treatment of early breast cancer. Cochrane Database Syst Rev 2007 Oct 17;(4):CD004421.