A Cochrane review included two trials. The effect of vaginal disinfection on the risk of MTCT of HIV (OR 0.93, 95% CI 0.65–1.33, n=708), neonatal death (OR 1.38, 95% CI 0.30–6.33, n=111), and death after the neonatal period (OR 1.45, 95% CI 0.47–4.45, n=104) is uncertain. There was no evidence that vaginal disinfection increased adverse effects in mothers (OR 1.15, 95% CI 0.41–3.22), and evidence from one trial showed that adverse effects decreased in neonates (OR 0.14, 95% CI 0.07–0.31).
Comment: The quality of evidence is downgraded by low quality of the larger study and by sparse data.