The quality of evidence is downgraded by study limitations (several shortcomings in study quality) and by inconsistency (unexplained variability in results).
A Cochrane review included 59 studies with a total of 13342 subjects. Motivational interviewing (MI) is a client-centred, semi-directive method for enhancing intrinsic motivation to change by exploring and resolving ambivalence. Compared to no treatment MI showed an effect on substance use which was strongest at post-intervention (SMD 0.79, 95% CI 0.48 to 1.09; 4 trials, n=202) and weaker at short (SMD 0.17, 95% CI 0.09 to 0.26; 15 trials, n=2327), and medium follow-up (SMD 0.15, 95% CI 0.04 to 0.25; 15 trials, n=2224). For long follow-up, the effect was not significant.
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