Antibiotics for prelabour rupture of membranes at or near term

Antibiotics for women with prelabour rupture of membranes at or near term (term PROM) may reduce maternal infectious morbidity, but information of adverse effects is insufficient and there are no clear neonatal benefits.

A Cochrane review included 4 trials involving a total of 2639 women. The use of antibiotics resulted in a statistically nonsignificant reduction in maternal chorioamnionitis and/or endometritis (RR 0.48, 95% CI 0.20 to 1.15; 4 trials, n=2639) or in endometritis (RR 0.34, 95% CI 0.05 to 2.31). No statistically significant differences were shown for outcomes of neonatal morbidity. Conclusions are limited by rare event rates for important outcomes. Subgroup analyses by timing of induction (early induction versus late induction) showed no difference in either probable or definite early-onset neonatal sepsis.

Comment: The quality of evidence is downgraded by imprecise results (wide confidence intervals and few outcome events).

Ədəbiyyat

1. Flenady V, King J. Antibiotics for prelabour rupture of membranes at or near term. Cochrane Database Syst Rev 2002;(3):CD001807 [Review content assessed as up-to-date: 31 July 2014].