Comparison of intrauterine and intracervical insemination with frozen donor sperm

Intra-uterine insemination increases live birth rates and pregnancy rates compared to cervical insemination in stimulated cycles using cryopreserved sperm for donor insemination.

A Cochrane review included 4 studies with a total of 208 subjects. Insemination of donor sperm is a fertility treatment for women who are unable to conceive with their partner or are single. All the included studies used cryopreserved sperm in stimulated cycles (gonadotrophin-stimulated cycles in 2 studies and clomiphene-stimulated cycles in 2 studies). Intra-uterine insemination after 6 cycles significantly improved live birth rates (OR 1.98, 95% CI 1.02 to 3.86) and pregnancy rates (OR 3.37, 95% CI 1.90 to 5.96) in comparison to cervical insemination. There was no statistically significant evidence of an effect on multiple pregnancies (OR 2.19, 95% CI 0.79 to 6.07) or miscarriages (RR 3.92, 95% CI 0.85 to 17.96).

A systematic review including 7 studies with a total of 444 subjects was abstracted in DARE. The pooled OR for success with intrauterine insemination was 2.4 (95% CI 1.5 to 3.8).

Ədəbiyyat

1. Besselink DE, Farquhar C, Kremer JA, Marjoribanks J, O'Brien P. Cervical insemination versus intra-uterine insemination of donor sperm for subfertility. Cochrane Database Syst Rev 2008 Apr 16;(2):CD000317 [Review content assessed as up-to-date: 16 February 2008].
2. Goldberg JM, Mascha E, Falcone T, Attaran M. Comparison of intrauterine and intracervical insemination with frozen donor sperm: a meta-analysis. Fertil Steril 1999 Nov;72(5):792-5.