According to a systemati review there is strong RCT evidence to support the use of cyclosporin, which was usually effective in inducing the remission of psoriasis when used in the dose range of 2.5 - 5.0 mg/kg/day. Doses above 5.0 mg/kg/day were associated with increased side-effects, which precluded any dose-related gains in efficacy. Maintenance treatment required a dose of 3.0 - 3.5 mg/kg/day, and although relapses were likely if the drug was given intermittently (as opposed to continuously), intermittent treatment appeared to be safer.