Interferon-alpha for hepatitis D (HDV) virus infection
Sübutlu məlumatların xülasələri
30.06.2017 • Sonuncu dəyişiklik 30.06.2017
Editors
Interferon-alpha appears to be only very modestly beneficial in patients with HDV infection, with poor long-term remission.
A systematic review including 5 RCTs with a total of 156 subjects and 10 uncontrolled studies (not included in the meta-analysis) was abstracted in DARE. The rate of response or remission was 18.4% in the treatment group and 1.5% in the control group. The best two results for long-term remission were 3.3% for lymphoblastoid IFN-alpha, and 8% for IFN-alpha 2b.
Comment: The quality of evidence is downgraded by sparse data.
Ədəbiyyat
- Malaguarnera M, Restuccia S, Pistone G, Ruello P, Giugno I, Trovato BA. A meta-analysis of interferon-alpha treatment of hepatitis D virus infection. Pharmacotherapy 1996 Jul-Aug;16(4):609-14.