Pulmonary embolism – Related resources
03.06.2016 • Sonuncu dəyişiklik 20.01.2017
This article is created and updated by the EBMG Editorial Team
Cochrane reviews
- Thrombolytic therapy is probably not effective for pulmonary embolism in haemodynamically stable patients .
- A negative D-dimer is useful in ruling out pulmonary embolism (PE) in patients who do not have a high pre-test probability of of PE .
Other evidence summaries
-
The sensitivity of different D-dimer assays is variable, but the ELISA methods in general appear to dominate the comparative ranking for sensitivity and negative likelihood ratio in the diagnosis of venous thromboembolism (deep venous thrombosis or pulmonary embolism) .
- Negative lung scan, spiral computed tomography in combination with ultrasound, or quantitative D-dimer assay are adequate to rule-out PE where the population prevalence is 35% or less. Positive high probability ventilation perfusion lung scan, spiral computed tomography, or ultrasound are adequate to rule-in PE where the population prevalence is 35% or greater .
- There appears not to be difference in heparin-associated thrombocytopenia (HAT) between low molecular weight heparin (LMWH) and unfractionated heparin (UFH) in treatment of pulmonary embolism and deep vein thrombosis .
Clinical guidelines
- Kearon C, Akl EA, Ornelas J et al. Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report. Chest 2016;149(2):315-52.
- Torbicki A, Perrier A, Konstantinides S, et al; Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology. Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 2008 Sep;29(18):2276-315.Epub 2008 Aug 30 .
Literature
Clinical practice reviews
Agnelli G, Becattini C. Acute pulmonary embolism. N Engl J Med 2010 Jul 15;363(3):266-74.