Meningitis – Related resources
26.02.2016 • Sonuncu dəyişiklik 01.09.2010
This article is created and updated by the EBMG Editorial Team
Cochrane reviews
- There may not be clinically important difference between ceftriaxone or cefotaxime and conventional antibiotics in the treatment of acute bacterial meningitis. Because of changing patterns of bacterial resistance, the use of alternatives to third generation cephalosporins should be restricted to situations where availability or affordability is an issue, and intravenous chloramphenicol should be used in combination with ampicillin .
- Corticosteroids should be routinely used in HIV-negative people with tuberculous meningitis to reduce death and disabling residual neurological deficit amongst survivors. There is not enough evidence to support or refute a similar conclusion for those who are HIV positive .
- Pre-hospital antibiotics may decrease mortality in meningococcal disease. Ceftriaxone and long-acting chloramphenicol appear to be equally effective and safe in preventing mortality and morbidity for suspected and confirmed cases .
Literature
- Logan SA, MacMahon E. Viral meningitis. BMJ 2008 Jan 5;336(7634):36-40.
Tunkel AR, Scheld WM. Corticosteroids for everyone with meningitis? N Engl J Med 2002 Nov 14;347(20):1613-5.
Hart C. Prophylactic antibiotics in contacts of patients with meningococcal disease. Clinical Evidence 2000;4:404–405
Scheld WM, Whitley RJ, Marra CM (edit). Infections of the central nervous system. 3rd edition 2004, Lippincott Williams et Wilkins Philadelphia, USA
- van de Beek D, de Gans J, Tunkel AR, Wijdicks EF. Community-acquired bacterial meningitis in adults. N Engl J Med 2006 Jan 5;354(1):44-53.
- Chaudhuri A, Martinez-Martin P, Kennedy PG, Andrew Seaton R, Portegies P, Bojar M, Steiner I, EFNS Task Force. EFNS guideline on the management of community-acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults. Eur J Neurol 2008 Jul;15(7):649-59.
Roos KL, ed. Principles of Neurologic Infectious Diseases. New York; McGraw-Hille, 2005