Memory complaints, mild cognitive impairment and dementia – Related resources
08.02.2012 • Sonuncu dəyişiklik 29.11.2010
This article is created and updated by the EBMG Editorial Team
Cochrane reviews
- Statins appear not to be effective in preventing Alzheimer’s disease or dementia given in late life to individuals at risk of vascular disease .
- Donepezil appears not to be effective in preventing the development of Alzheimer’s disease during 3 years’ treatment in patients with mild cognitive impairment (MCI, MMSE > 23) and its use is associated with a significant incidence of side effects. Donepezil appears to be associated with a modest and clinically questionable benefit on a 13-item the ADAS-Cog scale but not on other measures of cognitive function .
- In healthy elderly people cognitive interventions might possibly lead to performance improvements, although the evidence is insufficient .There is no good evidence to support the use of dietary or supplemental omega-3 fatty acids for the prevention of cognitive impairment or dementia .
- Blood pressure lowering appears to not prevent the development of dementia or cognitive impairment in hypertensive patients with no apparent prior cerebrovascular disease .
- Aerobic physical activities which improve cardiorespiratory fitness appear to be beneficial for cognitive function in healthy older adults without known cognitive impairment .
- Cholinesterase inhibitors do probably not have an effect on progression to dementia or cognitive test scores in mild cognitive impairment but may increase the risk of particularly gastrointestinal adverse events .
Literature
Clinical practice reviews
- Iliffe S, Pealing L. Subjective memory problems. BMJ 2010 Mar 19;340():c1425.