Male hypogonadism and hormone replacement – Related resources

Other Evidence summaries

• Testosterone supplementation during 6 months to older men with low to normal testosterone concentrations does not affect functional status or cognition but increases lean body mass and has mixed metabolic effects .

Clinical guidelines

• Bhasin S, Brito JP, Cunningham GR ym. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2018;103(5):1715-1744.

Literature

• Travison TG, Vesper HW, Orwoll E et al. Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe. J Clin Endocrinol Metab 2017;102(4):1161-1173.
• Ponce OJ, Spencer-Bonilla G, Alvarez-Villalobos N et al. The efficacy and adverse events of testosterone replacement therapy in hypogonadal men: A systematic review and meta-analysis of randomized, placebo-controlled trials. J Clin Endocrinol Metab 2018;103(5):1745-1754.
• Cunningham GR, Stephens-Shields AJ, Rosen RC et al. Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels. J Clin Endocrinol Metab 2016;101(8):3096-104.
• Snyder PJ, Kopperdahl DL, Stephens-Shields AJ et al. Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial. JAMA Intern Med 2017;177(4):471-479.
• Cheetham TC, An J, Jacobsen SJ et al. Association of Testosterone Replacement With Cardiovascular Outcomes Among Men With Androgen Deficiency. JAMA Intern Med 2017;177(4):491-499.
• Alexander GC, Iyer G, Lucas E et al. Cardiovascular Risks of Exogenous Testosterone Use Among Men: A Systematic Review and Meta-Analysis. Am J Med 2017;130(3):293-305.
• Budoff MJ, Ellenberg SS, Lewis CE et al. Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone. JAMA 2017;317(7):708-716.
Snyder PJ, Bhasin S, Cunningham GR et al. Effects of Testosterone Treatment in Older Men. N Engl J Med 2016;374(7):611-24. Yeap BB, Alfonso H, Chubb SA et al. In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality. J Clin Endocrinol Metab 2014;99(1):E9-18.
• Basaria S, Harman SM, Travison TG et al. Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial. JAMA 2015;314(6):570-81.
Wu FC, Tajar A, Beynon JM et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010;363(2):123-35.
• Basaria S, Coviello AD, Travison TG et al. Adverse events associated with testosterone administration. N Engl J Med 2010;363(2):109-22.
• Spitzer M, Huang G, Basaria S et al. Risks and benefits of testosterone therapy in older men. Nat Rev Endocrinol 2013;9(7):414-24.
• Xu L, Freeman G, Cowling BJ et al. Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med 2013;11():108.
• Vigen R, O'Donnell CI, Barón AE et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 2013;310(17):1829-36. Seftel A. Male hypogonadism. Part II: etiology, pathophysiology, and diagnosis. Int J Impot Res 2006 May-Jun;18(3):223-8. Seftel A. Testosterone replacement therapy for male hypogonadism: part III. Pharmacologic and clinical profiles, monitoring, safety issues, and potential future agents. Int J Impot Res 2007 Jan-Feb;19(1):2-24. Arver S, Lehtihet M. Current guidelines for the diagnosis of testosterone deficiency. Front Horm Res 2009;37():5-20. Jones TH. Late onset hypogonadism. BMJ 2009 Feb 13;338():b352. Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med 2004 Jan 29;350(5):482-92. Marks LS, Mazer NA, Mostaghel E, Hess DL, Dorey FJ, Epstein JI, Veltri RW, Makarov DV, Partin AW, Bostwick DG, Macairan ML, Nelson PS. Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial. JAMA 2006 Nov 15;296(19):2351-61.